Supplementary Table 2 Data Collected From 1 H To

supplementary table 2. data collected from 1 h to termination of hfnc hfnc success n = 37 hfnc failure n = 29 p variables

Supplementary Table 2. Data collected from 1 h to termination of HFNC
HFNC success
N = 37
HFNC failure
N = 29
p
Variables collected at 1 h of HFNC
pH
7.41 ± 0.05
7.42 ± 0.04
0.54
PaCO2, mmHg
41 ± 9
41 ± 9
0.78
PaO2/FIO2, mmHg
189 ± 90
130 ± 86
0. 06
Lactate, mmol/L
2.4 ± 1.2
2.0 ± 0.9
0.38
Heart rate, beats/min
88 ± 10
91 ± 16
0.34
Respiratory rate, breaths/min
22 ± 4
25 ± 6
0.03
Systolic blood pressure, mmHg
124 ± 16
125 ± 18
0.73
Diastolic blood pressure, mmHg
74 ± 8
70 ± 9
0.13
SpO2, %
96 (93-98)
93 (88-96)
＜0.01
ROX index
8.2 ± 2.2
6.2 ± 4.5
＜0.01
Flow, L/min
40 ± 10
44 ± 12
0.14
Variables collected at 2 h of HFNC
pH
7.41 ± 0.04
7.42 ± 0.07
0.60
PaCO2, mmHg
40 ± 10
39 ± 9
0.83
PaO2/FIO2, mmHg
197 ± 74
110 ± 70
0.03
Lactate, mmol/L
2.7 ± 1.2
2.1 ± 0.8
0.29
Heart rate, beats/min
88 ± 13
87 ± 17
0.88
Respiratory rate, breaths/min
21 ± 4
25 ± 8
0.08
Systolic blood pressure, mmHg
126 ± 13
126 ± 14
0.98
Diastolic blood pressure, mmHg
73 ± 8
74 ± 8
0.75
SpO2, %
96 (95-98)
94 (89-96)
＜0.01
ROX index
9.2 ± 2.6
7.0 ± 4.1
0.04
Flow, L/min
37 ± 10
46 ± 14
0.01
Variables collected at 4 h of HFNC
pH
7.40 ± 0.04
7.40 ± 0.07
0.88
PaCO2, mmHg
42 ± 8
43 ± 6
0.68
PaO2/FIO2, mmHg
212 ± 86
101 ± 18
＜0.01
Lactate, mmol/L
2.3 ± 1.1
2.1 ± 0.7
0.80
Heart rate, beats/min
84 ± 11
86 ± 19
0.69
Respiratory rate, breaths/min
21 ± 3
23 ± 6
0.10
Systolic blood pressure, mmHg
128 ± 11
122 ± 14
0.14
Diastolic blood pressure, mmHg
71 ± 9
71 ± 7
0.98
SpO2, %
97 (95-98)
94 (90-96)
＜0.01
ROX index
9.4 ± 2.8
7.0 ± 3.1
0.02
Flow, L/min
35 ± 9
43 ± 13
0.03
Variables collected at 8 h of HFNC
pH
7.44 ± 0.04
7.36 ± 0.10
0.07
PaCO2, mmHg
39 ± 5
47 ± 10
0.07
PaO2/FIO2, mmHg
214 ± 92
81 ± 10
0. 02
Lactate, mmol/L
2.3 ± 0.8
1.6 ± 0.6
0.16
Heart rate, beats/min
85 ± 17
92 ± 15
0.21
Respiratory rate, breaths/min
21 ± 4
25 ± 8
0.03
Systolic blood pressure, mmHg
128 ± 17
128 ± 14
0.96
Diastolic blood pressure, mmHg
71 ± 7
76 ± 10
0.08
SpO2, %
97 (96-98)
93 (90-96)
＜0.01
ROX index
9.2 ± 2.7
6.6 ± 3.1
＜0.01
Flow, L/min
36 ± 10
42 ± 12
0.07
Variables collected at 12 h of HFNC
pH
7.43 ± 0.04
7.42 ± 0.11
0.66
PaCO2, mmHg
37 ± 6
44 ± 9
0.04
PaO2/FIO2, mmHg
216 ± 89
120 ± 63
0.02
Lactate, mmol/L
2.3 ± 1.0
2.0 ± 0.9
0.50
Heart rate, beats/min
86 ± 14
90 ± 17
0.37
Respiratory rate, breaths/min
21 ± 4
25 ± 8
0.07
Systolic blood pressure, mmHg
125 ± 12
128 ± 16
0.47
Diastolic blood pressure, mmHg
72 ± 7
74 ± 12
0.35
SpO2, %
98 (96-99)
94 (90-96)
＜0.01
ROX index
9.0 ± 2.7
6.9 ± 3.8
0.03
Flow, L/min
37 ± 9
42 ± 12
0.09
Variables collected at 24 h of HFNC
pH
7.44 ± 0.04
7.43 ± 0.09
0.74
PaCO2, mmHg
39 ± 6
38 ± 8
0.68
PaO2/FIO2, mmHg
216 ± 148
129 ± 86
0.05
Lactate, mmol/L
2.2 ± 0.9
2.5 ± 1.4
0.44
Heart rate, beats/min
80 ± 10
90 ± 17
＜0.01
Respiratory rate, breaths/min
22 ± 4
25 ± 5
0.02
Systolic blood pressure, mmHg
125 ± 15
124 ± 18
0.85
Diastolic blood pressure, mmHg
72 ± 7
71 ± 13
0.57
SpO2, %
98 (96-99)
95 (90-98)
＜0.01
ROX index
9.0 ± 3.1
6.4 ± 2.6
＜0.01
Flow, L/min
40 ± 10
42 ± 11
0.45
White blood cell counts, ×109/L
9.7 ± 6.8
11.2 ± 3.8
0.38
Lymphocyte count, ×109/L
0.95 ± 0.56
0.65 ± 0.42
0.03
PCT, ng/mL
0.07 (0.04-0.10)
0.31 (0.18-0.73)
＜0.01
IL-6
40 (3-534)
62 (9-104)
0.42
C-reactive protein, mg/L
51 ± 41
100 ± 63
＜0.01
LDH, U/L
382 ± 105
486 ± 226
0.11
CD4, counts/μL
230 ± 109
180 ± 27
0.48
Variables collected at termination of HFNC
pH
7.40 ± 0.04
7.37 ± 0.15
0.34
PaCO2, mmHg
43 ± 7
50 ± 22
0.17
PaO2/FIO2, mmHg
250 ± 87
107 ± 75
＜0.01
Lactate, mmol/L
2.1 (1.6-2.4)
2.1 (1.5-4.3)
0.61
Heart rate, beats/min
84 ± 12
94 ± 28
0.07
Respiratory rate, breaths/min
19 ± 5
26 ± 9
＜0.01
Systolic blood pressure, mmHg
124 ± 15
115 ± 27
0.14
Diastolic blood pressure, mmHg
69 ± 9
64 ± 16
0.31
SpO2, %
98 (97-99)
89 (84-91)
＜0.01
ROX index
15.2 ± 6.1
5.1 ± 2.5
＜0.01
Flow, L/min
31 ± 8
48 ± 13
＜0.01
White blood cell counts, ×109/L
8.5 ± 6.2
11.6 ± 4.1
0.04
Lymphocyte counts, ×109/L
1.26 ± 0.53
0.67 ± 0.47
＜0.01
PCT, ng/mL
0.04 (0.03-0.10)
0.49 (0.17-0.90)
＜0.01
IL-6
7 (1-23)
67 (7-95)
0.03
C-reactive protein, mg/L
9 (3-21)
88 (40-142)
＜0.01
LDH, U/L
256 ± 85
462 ± 244
＜0.01
CD4, counts/μL
601 ± 359
193 ± 106
0.03
HFNC = high-flow nasal cannula, PCT = procalcitonin, LDH = lactate
dehydrogenase, ROX = the ratio of SpO2/FIO2 to respiratory rate
HFNC failure was defined as requirement of escalation therapy
(noninvasive ventilation or intubation).