54 Author True Positive False Positive False Negative True

54 author true positive false positive false negative true negative sensitivity (95% confidence interval) specificity

54
Author
True Positive
False Positive
False Negative
True Negative
Sensitivity (95% Confidence Interval)
Specificity (95% Confidence Interval)
Ong 2010
207
34
37
36
0.85 [0.80, 0.89]
0.51 [0.39, 0.64]
Farney 2011
1140
63
134
87
0.89 [0.88, 0.91]
0.58 [0.50, 0.66]
El-Sayed 2012
199
22
5
8
0.98 [0.94, 0.99]
0.27 [0.12, 0.46]
Yu 2012
78
11
13
12
0.86 [0.77, 0.92]
0.52 [0.31, 0.73]
Boynton 2013
139
26
30
24
0.82 [0.76, 0.88]
0.48 [0.34, 0.63]
Pereire 2013
104
7
12
5
0.90 [0.83, 0.95]
0.42 [0.15, 0.72]
Vana 2013
30
10
2
5
0.94 [0.79, 0.99]
0.33 [0.12, 0.62]
Cowan 2014
92
22
5
10
0.95 [0.88, 0.98]
0.31 [0.16, 0.50]
Ha 2014
90
12
21
16
0.81 [0.73, 0.88]
0.57 [0.37, 0.76]
Luo 2014
186
8
10
8
0.95 [0.91, 0.98]
0.50 [0.25, 0.75]
Reis 2015
157
24
11
23
0.93 [0.89, 0.97]
0.49 [0.34, 0.64]
Polysomnography Positive
Polysomnography Negative
STOP-Bang Positive
True Positive
False Positive
STOP-Bang Negative
False Negative
True Negative
S1 Table – Tables describing 2x2 contingency values and predictive
parameter of individual studies for all OSA (AHI ≥5), moderate to
severe (AHI ≥15) and severe OSA (AHI ≥30)
S1A: Description of 2X2 contingency table
S1B: 2X2 contingency table for Sleep Clinic Population - All OSA or
AHI ≥5
S1C: 2X2 contingency table for Surgical Population - All OSA or AHI ≥5
Author
True Positive
False Positive
False Negative
True Negative
Sensitivity (95% Confidence Interval)
Specificity (95% Confidence Interval)
Chung 2008
102
24
20
31
0.84 [0.76, 0.90]
0.56 [0.42, 0.70]
Chung 2012
429
141
81
95
0.84 [0.81, 0.87]
0.40 [0.34, 0.47]
S1D: 2X2 contingency table for Sleep Clinic Population - Moderate to
Severe OSA or AHI ≥15
Author
True Positive
False Positive
False Negative
True Negative
Sensitivity (95% Confidence Interval)
Specificity (95% Confidence Interval)
Ong 2010
151
90
15
58
0.91 [0.86, 0.95]
0.39 [0.31, 0.48]
Farney 2011
895
307
64
158
0.93 [0.92, 0.95]
0.34 [0.30, 0.38]
El-Sayed 2012
198
30
5
1
0.98 [0.94, 0.99]
0.03 [0.00, 0.17]
Yu 2012
62
27
5
20
0.93 [0.83, 0.98]
0.43 [0.28, 0.58]
Boynton 2013
96
69
7
47
0.93 [0.86, 0.97]
0.41 [0.32, 0.50]
Pereire 2013
82
29
6
11
0.93 [0.86, 0.97]
0.28 [0.15, 0.44]
Vana 2013
18
22
1
6
0.95 [0.74, 1.00]
0.21 [0.08, 0.41]
Cowan 2014
56
56
0
17
1.00 [0.94, 1.00]
0.23 [0.14, 0.35]
Ha 2014
72
30
12
25
0.86 [0.76, 0.92]
0.45 [0.32, 0.59]
Luo 2014
164
30
6
12
0.96 [0.92, 0.99]
0.29 [0.16, 0.45]
Reis 2015
113
68
5
29
0.96 [0.90, 0.99]
0.30 [0.21, 0.40]
S1E: 2X2 contingency table for Surgical Population - Moderate to
Severe OSA or AHI ≥15
Author
True Positive
False Positive
False Negative
True Negative
Sensitivity (95% Confidence Interval)
Specificity (95% Confidence Interval)
Chung 2008
65
61
5
46
0.93 [0.84, 0.98]
0.43 [0.33, 0.53]
Chung 2012
256
314
29
147
0.90 [0.86, 0.93]
0.32 [0.28, 0.36]
S1F: 2X2 contingency table for Other Miscellaneous studies - Moderate
to Severe OSA or AHI ≥15
Author
True Positive
False Positive
False Negative
True Negative
Sensitivity (95% Confidence Interval)
Specificity (95% Confidence Interval)
Firat 2012
40
20
6
19
0.87 [0.74, 0.95]
0.49 [0.32, 0.65]
Nicholl 2013
68
69
5
30
0.93 [0.85, 0.98]
0.30 [0.21, 0.40]
Silva 2011
534
2920
69
1247
0.89 [0.86, 0.91]
0.30 [0.29, 0.31]
S1G: 2X2 contingency table for Sleep Clinic Population - Severe OSA or
AHI ≥30
Author
True Positive
False Positive
False Negative
True Negative
Sensitivity (95% Confidence Interval)
Specificity (95% Confidence Interval)
Ong 2010
108
133
5
68
0.96 [0.90, 0.99]
0.34 [0.27, 0.41]
Farney 2011
555
647
25
197
0.96 [0.94, 0.97]
0.23 [0.21, 0.26]
El-Sayed 2012
146
78
2
4
0.99 [0.95, 1.00]
0.05 [0.01, 0.12]
Yu 2012
46
43
0
25
1.00 [0.92, 1.00]
0.37 [0.25, 0.49]
Boynton 2013
60
105
2
52
0.97 [0.89, 1.00]
0.33 [0.26, 0.41]
Pereire 2013
54
57
2
15
0.96 [0.88, 1.00]
0.21 [0.12, 0.32]
Ha 2014
44
58
7
30
0.86 [0.74, 0.94]
0.34 [0.24, 0.45]
Luo 2014
125
69
3
15
0.98 [0.93, 1.00]
0.18 [0.10, 0.28]
Reis 2015
61
120
1
34
0.98 [0.91, 1.00]
0.22 [0.16, 0.29]
S1H: 2X2 contingency table for Surgical Population - Severe OSA or AHI
≥30
Author
True Positive
False Positive
False Negative
True Negative
Sensitivity (95% Confidence Interval)
Specificity (95% Confidence Interval)
Chung 2008
39
87
0
51
1.00 [0.91, 1.00]
0.37 [0.29, 0.46]
Chung 2012
127
443
7
169
0.95 [0.90, 0.98]
0.28 [0.24, 0.31]
S1I: 2X2 contingency table for Other Miscellaneous studies - Severe
OSA or AHI ≥30
Author
True Positive
False Positive
False Negative
True Negative
Sensitivity (95% Confidence Interval)
Specificity (95% Confidence Interval)
Nicholl 2013
49
89
1
33
0.98 [0.89, 1.00]
0.27 [0.19, 0.36]
Silva 2011
320
3134
25
1291
0.93 [0.89, 0.95]
0.29 [0.28, 0.31]
S1J: Ong et al. 2010; Sleep Clinic Population - All OSA or AHI ≥5
Statistic
Formula
Value
95% CI
Sensitivity

84.84%
79.71% to 89.09%
Specificity

51.43 %
39.17% to 63.56%
Positive Likelihood Ratio

1.75
1.36 to 2.24
Negative Likelihood Ratio

0.29
0.20 to 0.43
Disease prevalence

77.71% (*)
72.69% to 82.19%
Positive Predictive Value

85.89% (*)
80.85% to 90.03%
Negative Predictive Value

49.32 % (*)
37.40% to 61.28%
S1K: Farney et al. 2011; Sleep Clinic Population - All OSA or AHI ≥5
Statistic
Formula
Value
95% CI
Sensitivity

89.48%
87.67% to 91.11%
Specificity

58.00 %
49.68% to 66.00%
Positive Likelihood Ratio

2.13
1.76 to 2.57
Negative Likelihood Ratio

0.18
0.15 to 0.22
Disease prevalence

89.47% (*)
87.75% to 91.01%
Positive Predictive Value

94.76% (*)
93.35% to 95.95%
Negative Predictive Value

39.37 % (*)
32.88% to 46.14%
S1L: El-Sayed et al. 2012; Sleep Clinic Population - All OSA or AHI ≥5
Statistic
Formula
Value
95% CI
Sensitivity

97.55%
94.37% to 99.20%
Specificity

26.67 %
12.28% to 45.89%
Positive Likelihood Ratio

1.33
1.07 to 1.65
Negative Likelihood Ratio

0.09
0.03 to 0.26
Disease prevalence

87.18% (*)
82.21% to 91.18%
Positive Predictive Value

90.05% (*)
85.32% to 93.66%
Negative Predictive Value

61.54 % (*)
31.58% to 86.14%
S1M: Yu et al. 2012; Sleep Clinic Population - All OSA or AHI ≥5
Statistic
Formula
Value
95% CI
Sensitivity

85.71%
76.81% to 92.17%
Specificity

52.17 %
30.59% to 73.18%
Positive Likelihood Ratio

1.79
1.16 to 2.77
Negative Likelihood Ratio

0.27
0.14 to 0.52
Disease prevalence

79.82% (*)
71.28% to 86.76%
Positive Predictive Value

87.64% (*)
78.96% to 93.67%
Negative Predictive Value

48.00 % (*)
27.80% to 68.69%
S1N: Boynton et al. 2013; Sleep Clinic Population - All OSA or AHI ≥5
Statistic
Formula
Value
95% CI
Sensitivity

82.25%
75.64% to 87.69%
Specificity

48.00 %
33.66% to 62.58%
Positive Likelihood Ratio

1.58
1.20 to 2.08
Negative Likelihood Ratio

0.37
0.24 to 0.57
Disease prevalence

77.17% (*)
71.03% to 82.55%
Positive Predictive Value

84.24% (*)
77.77% to 89.44%
Negative Predictive Value

44.44 % (*)
30.92% to 58.60%
S1O: Pereira et al. 2013; Sleep Clinic Population - All OSA or AHI ≥5
Statistic
Formula
Value
95% CI
Sensitivity

89.66%
82.63% to 94.54%
Specificity

41.67 %
15.17% to 72.33%
Positive Likelihood Ratio

1.54
0.95 to 2.49
Negative Likelihood Ratio

0.25
0.11 to 0.59
Disease prevalence

90.62% (*)
84.20% to 95.06%
Positive Predictive Value

93.69% (*)
87.44% to 97.43%
Negative Predictive Value

29.41 % (*)
10.31% to 55.96%
S1P: Vana et al. 2013; Sleep Clinic Population - All OSA or AHI ≥5
Statistic
Formula
Value
95% CI
Sensitivity

93.75%
79.19% to 99.23%
Specificity

33.33 %
11.82% to 61.62%
Positive Likelihood Ratio

1.41
0.97 to 2.03
Negative Likelihood Ratio

0.19
0.04 to 0.86
Disease prevalence

68.09% (*)
52.88% to 80.91%
Positive Predictive Value

75.00% (*)
58.80% to 87.31%
Negative Predictive Value

71.43 % (*)
29.04% to 96.33%
S1Q: Cowan et al. 2014; Sleep Clinic Population - All OSA or AHI ≥5
Statistic
Formula
Value
95% CI
Sensitivity

94.85%
88.38% to 98.31%
Specificity

31.25 %
16.12% to 50.01%
Positive Likelihood Ratio

1.38
1.09 to 1.75
Negative Likelihood Ratio

0.16
0.06 to 0.45
Disease prevalence

75.19% (*)
66.82% to 82.37%
Positive Predictive Value

80.70% (*)
72.25% to 87.49%
Negative Predictive Value

66.67 % (*)
38.38% to 88.18%
S1R: Ha et al. 2014; Sleep Clinic Population - All OSA or AHI ≥5
Statistic
Formula
Value
95% CI
Sensitivity

81.08%
72.55% to 87.89%
Specificity

57.14 %
37.18% to 75.54%
Positive Likelihood Ratio

1.89
1.22 to 2.93
Negative Likelihood Ratio

0.33
0.20 to 0.55
Disease prevalence

79.86% (*)
72.22% to 86.18%
Positive Predictive Value

88.24% (*)
80.35% to 93.77%
Negative Predictive Value

43.24 % (*)
27.10% to 60.51%
S1S: Luo et al. 2014; Sleep Clinic Population - All OSA or AHI ≥5
Statistic
Formula
Value
95% CI
Sensitivity

94.90%
90.82% to 97.53%
Specificity

50.00 %
24.65% to 75.35%
Positive Likelihood Ratio

1.90
1.16 to 3.10
Negative Likelihood Ratio

0.10
0.05 to 0.22
Disease prevalence

92.45% (*)
88.03% to 95.62%
Positive Predictive Value

95.88% (*)
92.04% to 98.20%
Negative Predictive Value

44.44 % (*)
21.53% to 69.24%
S1T: Reis et al. 2015; Sleep Clinic Population - All OSA or AHI ≥5
Statistic
Formula
Value
95% CI
Sensitivity

93.45%
88.59% to 96.69%
Specificity

48.94 %
34.08% to 63.94%
Positive Likelihood Ratio

1.83
1.38 to 2.43
Negative Likelihood Ratio

0.13
0.07 to 0.25
Disease prevalence

78.14% (*)
72.01% to 83.47%
Positive Predictive Value

86.74% (*)
80.92% to 91.32%
Negative Predictive Value

67.65 % (*)
49.47% to 82.61%
S1U: Chung et al. 2008; Surgical Population - All OSA or AHI ≥5
Statistic
Formula
Value
95% CI
Sensitivity

83.61%
75.82% to 89.69%
Specificity

56.36 %
42.32% to 69.70%
Positive Likelihood Ratio

1.92
1.40 to 2.61
Negative Likelihood Ratio

0.29
0.18 to 0.46
Disease prevalence

68.93% (*)
61.55% to 75.66%
Positive Predictive Value

80.95% (*)
73.00% to 87.40%
Negative Predictive Value

60.78 % (*)
46.11% to 74.16%
S1V: Chung et al. 2012; Surgical Population - All OSA or AHI ≥5
Statistic
Formula
Value
95% CI
Sensitivity

84.12%
80.65% to 87.18%
Specificity

40.25 %
33.94% to 46.81%
Positive Likelihood Ratio

1.41
1.26 to 1.57
Negative Likelihood Ratio

0.39
0.31 to 0.51
Disease prevalence

68.36% (*)
64.89% to 71.69%
Positive Predictive Value

75.26% (*)
71.51% to 78.75%
Negative Predictive Value

53.98 % (*)
46.32% to 61.50%
S1W: Ong et al. 2010; Sleep Clinic Population – Moderate to Severe OSA
or AHI ≥15
Statistic
Formula
Value
95% CI
Sensitivity

90.96%
85.53% to 94.85%
Specificity

39.19 %
31.28% to 47.54%
Positive Likelihood Ratio

1.50
1.30 to 1.72
Negative Likelihood Ratio

0.23
0.14 to 0.39
Disease prevalence

52.87% (*)
47.18% to 58.50%
Positive Predictive Value

62.66% (*)
56.22% to 68.78%
Negative Predictive Value

79.45 % (*)
68.38% to 88.02%
S1X: Farney et al. 2011; Sleep Clinic Population - Moderate to Severe
OSA or AHI ≥15
Statistic
Formula
Value
95% CI
Sensitivity

93.33%
91.56% to 94.82%
Specificity

33.98 %
29.68% to 38.48%
Positive Likelihood Ratio

1.41
1.32 to 1.51
Negative Likelihood Ratio

0.20
0.15 to 0.26
Disease prevalence

67.35% (*)
64.84% to 69.78%
Positive Predictive Value

74.46% (*)
71.89% to 76.90%
Negative Predictive Value

71.17 % (*)
64.73% to 77.04%
S1Y: El-Sayed et al. 2012; Sleep Clinic Population - Moderate to
Severe OSA or AHI ≥15
Statistic
Formula
Value
95% CI
Sensitivity

97.54%
94.35% to 99.20%
Specificity

3.23 %
0.08% to 16.70%
Positive Likelihood Ratio

1.01
0.94 to 1.08
Negative Likelihood Ratio

0.76
0.09 to 6.32
Disease prevalence

86.75% (*)
81.73% to 90.82%
Positive Predictive Value

86.84% (*)
81.75% to 90.94%
Negative Predictive Value

16.67 % (*)
0.42% to 64.12%
S1Z: Yu et al. 2012; Sleep Clinic Population - Moderate to Severe OSA
or AHI ≥15
Statistic
Formula
Value
95% CI
Sensitivity

92.54%
83.44% to 97.53%
Specificity

42.55 %
28.26% to 57.82%
Positive Likelihood Ratio

1.61
1.25 to 2.08
Negative Likelihood Ratio

0.18
0.07 to 0.43
Disease prevalence

58.77% (*)
49.17% to 67.91%
Positive Predictive Value

69.66% (*)
59.01% to 78.97%
Negative Predictive Value

80.00 % (*)
59.30% to 93.17%
S1Aa: Boynton et al. 2013; Sleep Clinic Population - Moderate to
Severe OSA or AHI ≥15
Statistic
Formula
Value
95% CI
Sensitivity

93.20%
86.50% to 97.22%
Specificity

40.52 %
31.50% to 50.03%
Positive Likelihood Ratio

1.57
1.34 to 1.84
Negative Likelihood Ratio

0.17
0.08 to 0.35
Disease prevalence

47.03% (*)
40.27% to 53.87%
Positive Predictive Value

58.18% (*)
50.26% to 65.80%
Negative Predictive Value

87.04 % (*)
75.10% to 94.63%
S1Ba: Pereira et al. 2013; Sleep Clinic Population - Moderate to
Severe OSA or AHI ≥15
Statistic
Formula
Value
95% CI
Sensitivity

93.18%
85.75% to 97.46%
Specificity

27.50 %
14.60% to 43.89%
Positive Likelihood Ratio

1.29
1.05 to 1.57
Negative Likelihood Ratio

0.25
0.10 to 0.62
Disease prevalence

68.75% (*)
59.96% to 76.65%
Positive Predictive Value

73.87% (*)
64.68% to 81.75%
Negative Predictive Value

64.71 % (*)
38.33% to 85.79%
S1Ca: Vana et al. 2013; Sleep Clinic Population - Moderate to Severe
OSA or AHI ≥15
Statistic
Formula
Value
95% CI
Sensitivity

94.74%
73.97% to 99.87%
Specificity

21.43 %
8.30% to 40.95%
Positive Likelihood Ratio

1.21
0.97 to 1.50
Negative Likelihood Ratio

0.25
0.03 to 1.88
Disease prevalence

40.43% (*)
26.37% to 55.73%
Positive Predictive Value

45.00% (*)
29.26% to 61.51%
Negative Predictive Value

85.71 % (*)
42.13% to 99.64%
S1Da: Cowan et al. 2014; Sleep Clinic Population - Moderate to Severe
OSA or AHI ≥15
Statistic
Formula
Value
95% CI
Sensitivity

100.00%
93.62% to 100.00%
Specificity

23.29 %
14.19% to 34.65%
Positive Likelihood Ratio

1.30
1.15 to 1.48
Negative Likelihood Ratio

0.00
Disease prevalence

43.41% (*)
34.71% to 52.42%
Positive Predictive Value

50.00% (*)
40.40% to 59.60%
Negative Predictive Value

100.00 % (*)
80.49% to 100.00%
S1Ea: Ha et al. 2014; Sleep Clinic Population - Moderate to Severe OSA
or AHI ≥15
Statistic
Formula
Value
95% CI
Sensitivity

85.71%
76.38% to 92.39%
Specificity

45.45 %
31.97% to 59.45%
Positive Likelihood Ratio

1.57
1.22 to 2.03
Negative Likelihood Ratio

0.31
0.17 to 0.57
Disease prevalence

60.43% (*)
51.79% to 68.62%
Positive Predictive Value

70.59% (*)
60.75% to 79.20%
Negative Predictive Value

67.57 % (*)
50.21% to 81.99%
S1Fa: Luo et al. 2014; Sleep Clinic Population - Moderate to Severe
OSA or AHI ≥15
Statistic
Formula
Value
95% CI
Sensitivity

96.47%
92.48% to 98.69%
Specificity

28.57 %
15.72% to 44.58%
Positive Likelihood Ratio

1.35
1.11 to 1.64
Negative Likelihood Ratio

0.12
0.05 to 0.31
Disease prevalence

80.19% (*)
74.18% to 85.33%
Positive Predictive Value

84.54% (*)
78.67% to 89.32%
Negative Predictive Value

66.67 % (*)
40.99% to 86.66%
S1Ga: Reis et al. 2015; Sleep Clinic Population - Moderate to Severe
OSA or AHI ≥15
Statistic
Formula
Value
95% CI
Sensitivity

95.76%
90.39% to 98.61%
Specificity

29.90 %
21.02% to 40.04%
Positive Likelihood Ratio

1.37
1.19 to 1.56
Negative Likelihood Ratio

0.14
0.06 to 0.35
Disease prevalence

54.88% (*)
47.97% to 61.66%
Positive Predictive Value

62.43% (*)
54.94% to 69.51%
Negative Predictive Value

85.29 % (*)
68.94% to 95.05%
S1Ha: Chung et al. 2008; Surgical Population - Moderate to Severe OSA
or AHI ≥15
Statistic
Formula
Value
95% CI
Sensitivity

92.86%
84.11% to 97.64%
Specificity

42.99 %
33.46% to 52.92%
Positive Likelihood Ratio

1.63
1.36 to 1.94
Negative Likelihood Ratio

0.17
0.07 to 0.40
Disease prevalence

39.55% (*)
32.29% to 47.16%
Positive Predictive Value

51.59% (*)
42.52% to 60.58%
Negative Predictive Value

90.20 % (*)
78.59% to 96.74%
S1Ia: Chung et al. 2012; Surgical Population - Moderate to Severe OSA
or AHI ≥15
Statistic
Formula
Value
95% CI
Sensitivity

89.82%
85.71% to 93.08%
Specificity

31.89 %
27.65% to 36.36%
Positive Likelihood Ratio

1.32
1.23 to 1.42
Negative Likelihood Ratio

0.32
0.22 to 0.46
Disease prevalence

38.20% (*)
34.70% to 41.80%
Positive Predictive Value

44.91% (*)
40.78% to 49.10%
Negative Predictive Value

83.52 % (*)
77.20% to 88.68%
S1Ja: Nunes et al. 2015; Sleep Clinic Population - Moderate to Severe
OSA or AHI ≥15
Statistic
Formula
Value
95% CI
Sensitivity

92.31%
79.13% to 98.38%
Specificity

7.14 %
1.50% to 19.48%
Positive Likelihood Ratio

0.99
0.88 to 1.12
Negative Likelihood Ratio

1.08
0.23 to 5.02
Disease prevalence

48.15% (*)
36.90% to 59.53%
Positive Predictive Value

48.00% (*)
36.31% to 59.85%
Negative Predictive Value

50.00 % (*)
11.81% to 88.19%
S1Ka: Ong et al. 2010; Sleep Clinic Population - Severe OSA or AHI ≥30
Statistic
Formula
Value
95% CI
Sensitivity

95.58%
89.98% to 98.55%
Specificity

33.83 %
27.32% to 40.82%
Positive Likelihood Ratio

1.44
1.30 to 1.61
Negative Likelihood Ratio

0.13
0.05 to 0.31
Disease prevalence

35.99% (*)
30.67% to 41.57%
Positive Predictive Value

44.81% (*)
38.43% to 51.33%
Negative Predictive Value

93.15 % (*)
84.74% to 97.74%
S1La: Farney et al. 2011; Sleep Clinic Population - Severe OSA or AHI
≥30
Statistic
Formula
Value
95% CI
Sensitivity

95.69%
93.70% to 97.19%
Specificity

23.34 %
20.53% to 26.34%
Positive Likelihood Ratio

1.25
1.20 to 1.30
Negative Likelihood Ratio

0.18
0.12 to 0.28
Disease prevalence

40.73% (*)
38.16% to 43.33%
Positive Predictive Value

46.17% (*)
43.33% to 49.04%
Negative Predictive Value

88.74 % (*)
83.83% to 92.58%
S1Ma: El-Sayed et al. 2012; Sleep Clinic Population - Severe OSA or
AHI ≥30
Statistic
Formula
Value
95% CI
Sensitivity

98.65%
95.20% to 99.84%
Specificity

4.88 %
1.34% to 12.02%
Positive Likelihood Ratio

1.04
0.98 to 1.09
Negative Likelihood Ratio

0.28
0.05 to 1.48
Disease prevalence

64.35% (*)
57.79% to 70.53%
Positive Predictive Value

65.18% (*)
58.55% to 71.40%
Negative Predictive Value

66.67 % (*)
22.28% to 95.67%
S1Na: Yu et al. 2012; Sleep Clinic Population - Severe OSA or AHI ≥30
Statistic
Formula
Value
95% CI
Sensitivity

100.00%
92.29% to 100.00%
Specificity

36.76 %
25.39% to 49.33%
Positive Likelihood Ratio

1.58
1.32 to 1.90
Negative Likelihood Ratio

0.00
Disease prevalence

40.35% (*)
31.27% to 49.95%
Positive Predictive Value

51.69% (*)
40.84% to 62.41%
Negative Predictive Value

100.00 % (*)
86.28% to 100.00%
S1Oa: Boynton et al. 2013; Sleep Clinic Population - Severe OSA or AHI
≥30
Statistic
Formula
Value
95% CI
Sensitivity

96.77%
88.83% to 99.61%
Specificity

33.12 %
25.82% to 41.07%
Positive Likelihood Ratio

1.45
1.28 to 1.63
Negative Likelihood Ratio

0.10
0.02 to 0.39
Disease prevalence

28.31% (*)
22.45% to 34.77%
Positive Predictive Value

36.36% (*)
29.03% to 44.20%
Negative Predictive Value

96.30 % (*)
87.25% to 99.55%
S1Pa: Pereira et al. 2013; Sleep Clinic Population - Severe OSA or AHI
≥30
Statistic
Formula
Value
95% CI
Sensitivity

96.43%
87.69% to 99.56%
Specificity

20.83 %
12.16% to 32.02%
Positive Likelihood Ratio

1.22
1.07 to 1.39
Negative Likelihood Ratio

0.17
0.04 to 0.72
Disease prevalence

43.75% (*)
35.00% to 52.79%
Positive Predictive Value

48.65% (*)
39.05% to 58.32%
Negative Predictive Value

88.24 % (*)
63.56% to 98.54%
S1Qa: Ha et al. 2014; Sleep Clinic Population - Severe OSA or AHI ≥30
Statistic
Formula
Value
95% CI
Sensitivity

86.27%
73.74% to 94.30%
Specificity

34.09 %
24.32% to 44.97%
Positive Likelihood Ratio

1.31
1.09 to 1.58
Negative Likelihood Ratio

0.40
0.19 to 0.85
Disease prevalence

36.69% (*)
28.68% to 45.28%
Positive Predictive Value

43.14% (*)
33.37% to 53.32%
Negative Predictive Value

81.08 % (*)
64.84% to 92.04%
S1Ra: Luo et al. 2014; Sleep Clinic Population - Severe OSA or AHI ≥30
Statistic
Formula
Value
95% CI
Sensitivity

97.66%
93.30% to 99.51%
Specificity

17.86 %
10.35% to 27.74%
Positive Likelihood Ratio

1.19
1.07 to 1.32
Negative Likelihood Ratio

0.13
0.04 to 0.44
Disease prevalence

60.38% (*)
53.45% to 67.01%
Positive Predictive Value

64.43% (*)
57.26% to 71.16%
Negative Predictive Value

83.33 % (*)
58.58% to 96.42%
S1Sa: Reis et al. 2015; Sleep Clinic Population - Severe OSA or AHI
≥30
Statistic
Formula
Value
95% CI
Sensitivity

98.39%
91.34% to 99.96%
Specificity

22.08 %
15.80% to 29.46%
Positive Likelihood Ratio

1.26
1.15 to 1.38
Negative Likelihood Ratio

0.07
0.01 to 0.52
Disease prevalence

28.70% (*)
22.77% to 35.23%
Positive Predictive Value

33.70% (*)
26.86% to 41.09%
Negative Predictive Value

97.14 % (*)
85.08% to 99.93%
S1Ta: Chung et al. 2008; Surgical Population - Severe OSA or AHI ≥30
Statistic
Formula
Value
95% CI
Sensitivity

100.00%
90.97% to 100.00%
Specificity

36.96 %
28.90% to 45.58%
Positive Likelihood Ratio

1.59
1.40 to 1.80
Negative Likelihood Ratio

0.00
Disease prevalence

22.03% (*)
16.16% to 28.87%
Positive Predictive Value

30.95% (*)
23.02% to 39.80%
Negative Predictive Value

100.00 % (*)
93.02% to 100.00%
S1Ua: Chung et al. 2012; Surgical Population - Severe OSA or AHI ≥30
Statistic
Formula
Value
95% CI
Sensitivity

94.78%
89.53% to 97.87%
Specificity

27.61 %
24.11% to 31.34%
Positive Likelihood Ratio

1.31
1.23 to 1.39
Negative Likelihood Ratio

0.19
0.09 to 0.39
Disease prevalence

17.96% (*)
15.27% to 20.91%
Positive Predictive Value

22.28% (*)
18.93% to 25.92%
Negative Predictive Value

96.02 % (*)
91.98% to 98.39%
S1Va: Firat et al. 2012; Other Miscellaneous study - Moderate to
Severe OSA or AHI ≥15
Statistic
Formula
Value
95% CI
Sensitivity

86.96%
73.74% to 95.06%
Specificity

48.72 %
32.42% to 65.22%
Positive Likelihood Ratio

1.70
1.22 to 2.35
Negative Likelihood Ratio

0.27
0.12 to 0.60
Disease prevalence

54.12% (*)
42.96% to 64.98%
Positive Predictive Value

66.67% (*)
53.31% to 78.31%
Negative Predictive Value

76.00 % (*)
54.87% to 90.64%
S1Wa: Nicholl et al. 2013; Other Miscellaneous study - Moderate to
Severe OSA or AHI ≥15
Statistic
Formula
Value
95% CI
Sensitivity

93.15%
84.74% to 97.74%
Specificity

30.30 %
21.47% to 40.35%
Positive Likelihood Ratio

1.34
1.16 to 1.54
Negative Likelihood Ratio

0.23
0.09 to 0.55
Disease prevalence

42.44% (*)
34.95% to 50.20%
Positive Predictive Value

49.64% (*)
40.99% to 58.30%
Negative Predictive Value

85.71 % (*)
69.74% to 95.19%
S1Xa: Silva et al. 2011; General Population - Moderate to Severe OSA
or AHI ≥15
Statistic
Formula
Value
95% CI
Sensitivity

88.56%
85.74% to 90.99%
Specificity

29.93 %
28.54% to 31.34%
Positive Likelihood Ratio

1.26
1.22 to 1.31
Negative Likelihood Ratio

0.38
0.30 to 0.48
Disease prevalence

12.64% (*)
11.71% to 13.62%
Positive Predictive Value

15.46% (*)
14.27% to 16.71%
Negative Predictive Value

94.76 % (*)
93.41% to 95.90%
S1Ya: Nicholl et al. 2013; Other Miscellaneous study - Severe OSA or
AHI ≥30
Statistic
Formula
Value
95% CI
Sensitivity

98.00%
89.35% to 99.95%
Specificity

27.05 %
19.41% to 35.84%
Positive Likelihood Ratio

1.34
1.20 to 1.51
Negative Likelihood Ratio

0.07
0.01 to 0.53
Disease prevalence

29.07% (*)
22.41% to 36.47%
Positive Predictive Value

35.51% (*)
27.55% to 44.10%
Negative Predictive Value

97.06 % (*)
84.67% to 99.93%
S1Za: Silva et al. 2011; General Population - Severe OSA or AHI ≥30
Statistic
Formula
Value
95% CI
Sensitivity

92.75%
89.49% to 95.26%
Specificity

29.18 %
27.84% to 30.54%
Positive Likelihood Ratio

1.31
1.26 to 1.36
Negative Likelihood Ratio

0.25
0.17 to 0.36
Disease prevalence

7.23% (*)
6.51% to 8.00%
Positive Predictive Value

9.26% (*)
8.32% to 10.28%
Negative Predictive Value

98.10 % (*)
97.21% to 98.77%
54