Study On Retinol Binding Protein (RBP) Receptor In Hydatidiform

study on retinol binding protein (rbp) receptor in hydatidiform mole trophoblastic cells staff : andrijono, e. taufik, m. hartati and r.

Study on Retinol Binding Protein (RBP) Receptor in
Hydatidiform Mole Trophoblastic Cells
Staff : Andrijono, E. Taufik, M. Hartati and R. Kodaria
Student : -
Sponsor : -
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Hydatidiform mole is an abnormal pregnancy characterized by the
proliferation of cytotrophoblastic, syncytiotrophoblastic, and
intermediate trophoblastic cells in histological specimens. Vitamin A
plays a role in controlling cell proliferation, and decrease in
vitamin A level will cause an uncontrollable proliferation. To date,
it is not known whether there is a relationship between vitamin A
deficiency and hydatidiform mole. This study aimed to demonstrate the
presence of retinol binding protein (RBP) receptors in the
hydatidiform mole trophoblastic cells, that would provide explanation
on the relationship of vitamin A and hydatidiform mole. The study was
a descriptive study. The specimens of the study were paraffin blocks
of hydatidiform mole made in 2005, and the examinations were performed
by indirect immunohistochemistry. We examined the distribution of the
cells showing expression of RBP receptor, the strength of expression,
and location of the expression. As many as 21 specimens were
collected, and the distributions of RBP receptor expression in
hydatidiform mole trophoblastic cells ranged from moderate to dense.
The expression in syncytiotrophoblastic cells was stronger than that
in cytotrophoblastic cells. Furthermore, the expressions were found in
the cell membranes and cytoplasm.
Keywords: cytotrophoblastic, syncytiotrophoblastic, intermediate
trophoblastic cells