Name Atef AbdelMonem AbdelHafez Current Statu S

name : atef abdel-monem abdel-hafez current statu s : professor date of birth : november 15, 1966 place of birth : assiut, egypt wo

Name : Atef Abdel-Monem Abdel-Hafez
Current Statu s : Professor
Date of Birth : November 15, 1966
Place of Birth : Assiut, Egypt
Work Address : Department of Pharmaceutical Medicinal Chemistry,
Faculty of
Pharmacy, Assiut University, Assiut, Egypt.
Home Address : Ismail El-Kabani Street, Mekka El-mokarama Tower, 3rd
floor,
Appartment No. 307, Assiut, Egypt.
Telephone: (2088)-2303006 Fax : (2088)-2332776
Mobile Phone : 0127433154 (In Egypt)
E-mail: [email protected]
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Educations:
*
B.Pharm.Sci. (Pharmaceutical Sciences) May 1989; Faculty of
Pharmacy, Assiut University, Assiut, Egypt,
*
M. Pharm. Sci. (Pharmaceutical Medicinal Chemistry) December 1995;
Faculty of Pharmacy, Assiut University, Assiut, Egypt
“Synthesis and investigation of 3(5)-amino (Chloro)-1,2,4
triazole-5(3)-carboxylic acidderivatives”
*
Ph.D. (Pharmaceutical Medicinal Chemistry) March 1999; Faculty of
Pharmacy, Assiut University, Assiut, Egypt.
“ Chemical and biochemical modifications of paeoniflorin and its major
metabolite paeonimetabolin-I, targeting neuropharmacological
activities”
Societies and Boards:
1990 Member of the Pharmaceutical Society of Egypt
1996-1998 Predoctoral work with Professor Masao Hattori, Department of
Cell
Resources Engineering, Institute of Natural Medicine, Toyama
Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-
0194, Japan.
1989 Member of the Egyptian Syndicate of Pharmacists
2000 Membership of the Pharmaceutical Society of Japan
2001 A referee in Bioorganic & Medicinal Chemistry Journal
2000-2002 Postdoctoral fellowship under the "Japan society for the
promotion
of science postdoctoral fellowship program for foreign researchers
in Japan for a period of 24 consecutive months" with Professor
Masao Hattori, Toyama Medical and Pharmaceutical University,
2630 Sugitani, Toyama 930-0194, Japan.
2003 Member of Who,sWho in Science and Engineering Encyclopedia 7th
Edition. 2003-2004
Research Interest:
*
Design, synthesis of novel medium-sized Macrolides.
*
Biotransformation of bioactive compounds by using human intestinal
bacteria.
*
Bio-activation of naturally isolated compounds by using human
intestinal bacteria.
*
Isolation and structural elucidation of naturally bioactive
compounds.
*
Chemical and biochemical modifications of lead compounds to
maximize the biological activity and reduce toxicity.
*
Design and synthesis of organic compounds of potential biological
activities.
*
Prodrugs and chemical delivery systems
Research Experiences:
*
Anaerobic fermentation methods
*
Enzymatic metabolism
*
Separation techniques of bacterial metabolites
*
Isolation and purification techniques
*
Chromatography (HPLC, GC, etc.
*
Modern spectroscopic techniques (2D-NMR, MS, CD, etc.)
*
Personal experience in carrying out the oral glucose tolerance
test in mice or rats, the anticonvulsant activity using Sc PTZ
seizure test and Scopolamine-induced amnesia using passive
avoidance task.
Review articles and Books:
1.
Review article on “Anti-aging Drugs”.
2.
Topics in Medicinal Chemistry Volume I and II.
3.
Practical Pharmaceutical Chemistry Volume I and II.
List of Publications
1.
Synthesis and Investigation of Certain
3(5)-Substituted-1,2,4-Triazole-5(3)-Carboxylic Acid Derivatives.
Atef Abdel-Monem Abdel-Hafez, H. M. Mohameds, H.Y. Hassan, G. S.
El-Karamany, N. A. El-Koussi and A. F. Youssef. Bulletin of
Pharmaceutical Sciences, Assuit University, 20 (1997), 47-61.
2.
Potent Anticonvulsant Paeonimetabolin-I Derivatives Obtained by
incubation of Paeoniflorin and Thiol Compounds with Lactobacillus
brevis.
Atef Abdel-Monem Abdel-Hafez, Meselhy R. Meselhy, Norio Nakamura,
Masao Hattori, Hiroshi Watanabi, Tarek A. Mohamed, Nadia M. Mahfouz
and Mahmoud A. El-Gendy
Chemical Pharmaceutical Bulletin, 46 (1998), 1486-1487.
3.
Effects of Paeoniflorin Derivatives on Scopolamine-Induced Amnesia
Using a Passive Avoidance Task in Mice; Structure-Activity
Relationship.
Atef Abdel-Monem Abdel-Hafez, Meselhy R. Meselhy, Norio Nakamura,
Masao Hattori, Hiroshi Watanabi, Yukihisa Murakami, Mahmoud A.
El-Gendy, Nadia M. Mahfouz, and Tarek A. Mohamed. Biological
Pharmaceutical Bulletin, 21 (1998), 1174-1179.
4.
Anticonvulsant Activity of Paeonimetabolin-I Adducts Obtained by
Incubation of Paeoniflorin and Thiol Compounds with Lactobacillus
brevis.
Atef Abdel-Monem Abdel-Hafez, Meselhy R. Meselhy, Norio Nakamura,
Masao Hattori, Hiroshi Watanabi, Yukihisa Murakami, Mahmoud A.
El-Gendy, Nadia M. Mahfouz, and Tarek A. Mohamed
5.
Biological Pharmaceutical Bulletin, 22 (1999), 491-497New
Paeonilactone-A Adducts Formed by Anaerobic Incubation of
Paeoniflorin with Lactobacillus brevis in the Presence of
Arylthiols.
Atef Abdel-Monem Abdel-Hafez, Meselhy R. Meselhy, Norio Nakamura,
Masao Hattori, Mahmoud A. El-Gendy, Nadia M. Mahfouz, and Tarek A.
Mohamed
Chemical Pharmaceutical Bulletin, 49 (2001), 918-920.
6.
Biotransformation of Phorbol by Human Intestinal Bacteria.
Atef Abdel-Monem Abdel-Hafez, Norio Nakamura, and Masao Hattori
Chemical Pharmaceutical Bulletin, 50 (2002), 160-164.
7.
Inhibition of Cytopathic Effect of Human Immuondeficiency Virus
Type-I by Various Phorbol Derivatives.
Sahar El-Mekkawy, Meselhy Ragab Meselhy, Atef Abdel-Monem Abdel-Hafez,
Norio Nakamura, Masao Hattori, Takuya Kawahata, and Toru Otake
Chemical Pharmaceutical Bulletin, 50 (2002), 523-529.
8.
An Efficient, Convenient Synthysis of Novel Medium-Sized
13H-Dibenzo[d,h][1,3,7] oxadiazecine-8,14-dione Macrolides as
Anticipated Antineoplastic Agents.
Atef Abdel-Monem Abdel-Hafez. Bioorganic & Medicinal Chemistry, 10
(2002), 2297-2302.
9.
Synthesis and Evaluation of Anti-HIV-I and Anti-HSV-I Activities
of 4H-[1,2,4]-Triazolo [1,5-a]pyrimidin-5-one. Atef Abdel-Monem
Abdel-Hafez, Hosny A. H. Elsherief, Michiko Jo, Masahiko Kurokawa,
Kimiyasu Shiraki, Takuya Kawahata, Toru Otake, Norio Nakamura, and
Masao Hattori . Arzniem-Forsch/Drug Res., 52 (2002) 833-839.
10.
Transformation of Arctiin to Estrogenic and Antiestrogenic
Substances by Human Intestinal Bacteria. Li-Hua Xie, Eun-Mi Ahn,
Teruaki Akao, Atef Abdel-Monem Abdel-Hafez, Norio Nakamura, and
Masao Hattori. Chemical Pharmaceutical Bulletin, 51 (2003),
378-384.
11.
Synthesis and Anticonvulsant Evaluation of Some
N-substituted-isoindolinedione
Derivatives. Atef Abdel-Monem Abdel-Hafez.Archives of Pharmacal
Reseach, 27 (2004), 495-501.
12.
Design and Synthesis of Some Styrylisoxazole carboxylic Acid
Derivatives as Anti- inflammatory Agents. Farghaly A. Omer, Atef
Abdel-Monem Abdel-Hafez, and
Montaser S. Ahmed. Bulletin of Pharmaceutical Sciences, Assuit
University, 51 (2004), 171-188.
13.
Benzimidazole Condensed Ring Systems: New Synthesis and
Antineoplastic Activity of Substituted 3,4-Dihydro- and
1,2,3,4-Tetrahydro-benzo[4,5]imidazo [1,2-a]pyrimidine
Derivatives. Atef Abdel-Monem Abdel-Hafez
Archives of Pharmacal Reseach, 30 (2007), 678-684.
14.
Design, synthesis and docking studies of new
1,3,4-thiadiazole-2-thione derivatives with carbonic anhydrase
inhibitory activity.
Mohammed K. Abdel-Hamid, Atef A. Abdel-Hafez, Nawal, A. El-Koussi,
Nadia M.
Mahfouz, and Claudiu T. Supuran. Bioorganic & Medicinal Chemistry, 15
(2007), 6975-6984.